Intracellular free calcium concentration and oxidative damage in erythrocytes from workers occupationally exposed to organophosphate pesticides by Martha-Angelica Quintanar-Escorza in Journal of Clinical Case Reports MedicaI Images and Health Sciences
Intracellular free calcium concentration and oxidative damage in erythrocytes from workers occupationally exposed to organophosphate pesticides by Martha-Angelica Quintanar-Escorza in Journal of Clinical Case Reports MedicaI Images and Health Sciences Abstract Background: Organophosphate (OP) pesticides inhibit the activity of acetylcholinesterase (AChE) in the central nervous system, causing changes in the oxidative state that could be considered as another mechanism of toxicity in erythrocytes related to the concentration of free intracellular calcium ([Ca2 +] i). Aims: In the present work, the parameters of the oxidative state and [Ca2+]i were evaluated in workers occupationally exposed to OP. Methods: A comparative and cross-sectional study was conducted in exposed and not exposed to organophosphate pesticides in their workplace and working day (31 subjects per group). In the case of exposure, selected workers with an exposure ≥5 years and with an ac...