Visceral Leishmaniasis presenting with Hemophagocytosis and Myelodysplasia: A Case report and review of the literature in Annika Kasprzak by Journal of Clinical Case Reports Medical Images and Health Sciences
Visceral Leishmaniasis presenting with Hemophagocytosis and Myelodysplasia: A Case report and review of the literature in Annika Kasprzak by Journal of Clinical Case Reports Medical Images and Health Sciences Abstract A 62-year-old patient presented with fever persisting despite antibiotic treatment, weight loss and sweating for a period of several weeks. On physical examinations hepatosplenomegaly was noticed. Increasing pancytopenia triggered bone marrow biopsy, showing expanded and dysplastic erythropoiesis, dysmegakaryopoiesis and hypoplastic granulopoiesis. The patient was diagnosed with low-risk myelodysplastic syndrome (MDS). Bone marrow cells displayed a normal karyotype. Infectious disease diagnostics were negative. During the course of the disease liver enzymes, d-dimers, laboratory markers of inflammation, coagulation parameters and pancytopenia worsened. Liver puncture revealed severe hemophagocytic syndrome. Treatment with corticosteroids and etoposide was initiate...