Sustained hyperactivity and lower blood pressure are influenced by the ANXRR16 chromosomic region in rats by Izídio, G. S in Journal of Clinical Case Reports MedicaI Images and Health Sciences
Sustained hyperactivity and lower blood pressure are influenced by the ANXRR16 chromosomic region in rats by Izídio, G. S in Journal of Clinical Case Reports MedicaI Images and Health Sciences Abstract Objectives: Quantitative Trait Locus (QTL) mapping is a virtuous strategy to find chromosomic regions related to behavioral traits in rats. We have mapped a QTL, on rat chromosome 4, called Anxrr16 (anxiety-related response 16) that modulates the central locomotion in the open-field (OF). To specifically study the Anxrr16 effects, we developed the congenic SLA16 (SHR.LEW-Anxrr16) rat strain. Methods: Here, males and females from SLA16 and SHR (Spontaneously Hypertensive Rat) strain were (i) repeatedly evaluated in the OF throughout their entire lives (4 weeks to 24 months); (ii) evaluated for their systolic blood pressure; (iii) and repeatedly treated (from postnatal days 28 to 44) with methylphenidate (MPH, Ritalina®, 2 mg/kg) or vehicle...